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10.1038/nature09922 81 WangZ.RobertsA

This increase was blocked by pretreatment with LY294002 or BAY11-7082

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(A) Significant decrease in glutathione levels in CA proportional to farnesol concentration and time of exposure with minimal decrease in glutathione in cdr1

Instead of acting solely within mitochondria, CoQ 10 can be distributed to membranes such as the ER, plasma membrane and LDs, where its reduced form, ubiquinol, suppresses lipid peroxidation 17,22,36

Standard maintenance therapy typically involves hydroxocobalamin 1mg injections every two to three months for patients without neurological involvement