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Some are approved to lower heart disease risk, and the FDA has cleared semaglutide to reduce the risk of heart attack, stroke, and cardiovascular death in adults with established heart disease and either obesity or overweight, a milestone first reported through the landmark SELECT trial summarized by Yale Medicine

Evertts, A.G., Wang, X., Manning, A.L., Dyson, N.J., Garcia, B.A., and Coller, H.A., "H4K20 methylation functions in quiescence and chromatin compaction", Molecular Biology of the Cell 24 (19): 3025-3037 (2014)