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Exposure to excess haem-iron was only found to promote a persistent phenotype in experimental OM models for NTHi strains previously starved of haem-iron, compared to those continuously exposed to haem-replete conditions (Szelestey et al., 2013

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However, their therapeutic potential could be limited as a protracted use will lead to tolerance to analgesic effects requiring escalating doses that is associated with side effects such as respiratory depression

Discontinuation and Reinitiation of GLP-1 Receptor Agonists Among US Adults with Overweight or Obesity

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