In preclinical hepatocyte and rodent models, the compound is studied for its effects on lipogenesis, -oxidation enzymes, and de-novo lipogenic transcription factors such as SREBP-1c and ChREBP
And a path to bariatric surgery if appropriate, he said, adding that the program delivers 19% sustained weight loss at 36 months
GLP-1 therapy offers a potential pathway to address those residual symptoms
Looking forwards: future avenues of research for incretin biology Looking forwards: future avenues of research for incretin biology Several factors hampered (and continue to challenge) clinical development of GLP agonist therapies
Contraindicated in personal/family history of MEN-2 or medullary thyroid carcinoma
Anzawa D, Mawatari T, Tanaka Y, Yamamoto M, Genda T, Takahashi S, et al