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Polypharmacy remains a major challenge for both patients and healthcare providers

Activation of wound healing and tissue repair signaling

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Although initial findings suggest that GLP-1Ra leads to a slight reduction in bone mineral density and promotes bone remodeling, favoring resorption similar to calorie restriction effects, further research is needed to explore the effects of GLP-1Ra on bone metabolism and fracture-related outcomes, as well as dual- and triple-receptor agonists of GLP-1, glucose-dependent insulinotropic polypeptide (GIP), and glucagon in PwO

It has been discovered that GLP-1RAs mRNA is expressed in the cerebral cortex, hippocampus, thalamus, and hypothalamus