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Gastrointestinal effects GI side effects dominate the adverse event profile, consistent with all GLP-1 receptor agonists

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Crucially, HBV independently suppresses DNA repair capacity by downregulating poly(ADP-ribose) polymerase 1 (PARP1) via YTHDF2-mediated m6A methylationwithout enhancing ROS production or altering oxidative stress pathways [389, 391]

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Hoffmann-La Roche Ltd) is a Swiss company founded in 1896, now one of the worlds largest biotechnology and diagnostics firms ( [13] )