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Despite these improvements imparted to Nle1-AngIV to construct pharmacokineticly superior Dihexa, Dihexa should not be considered the optimal drug candidate

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For example, some patients feel mild nausea or fullness even after years

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While the findings underscore spermidines potential as an agent for healthy aging, the underlying mechanisms and its effects on telomeres and longevity require further elucidation in human studies

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