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doi: 10.3389/fphar.2024.1447097 Received 11 June 2024 Accepted 09 September 2024 Published 30 September 2024 Volume 15 - 2024 Edited by Fabrcio Souza Silva, Federal University of So Francisco Valley, Brazil Reviewed by Kevin Spelman, Health, Education and Research, United States Minhajur Rahman, University of Chittagong, Bangladesh Updates Copyright 2024 Moradi, Khazaei, Tarlan, Jasemi, Joshi, Aneva, Farzaei and Echeverra

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182 In two subsequent studies, low-dose curcumin showed a non-significant trend toward lowering total cholesterol and LDL cholesterol in acute coronary patients, 183 while high dose-curcumin (14 grams/day) exhibited non-significant increases in total-, LDL-, and HDL cholesterol

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In addition, intraperitoneal administration of butyric acid exhibited a decline in follicular count, LH, testosterone and insulin level, and increased FSH and estradiol level in obese PCOS mice (65)