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Shingina A, Mukhtar N, Wakim-Fleming J, Alqahtani S, Wong RJ, Limketkai BN, Larson AM, Grant L

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Users stopping niacinamide typically experience very gradual benefit decline over 1-3 months without dramatic reversal, maintaining 40-60% of improvements long-term if treatment lasted 6+ months, and tolerating breaks or cycling without rebound effects or significant regression concerns

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10.3389/fragi.2025.1449485 55 KordiN.SaydiA.KaramiS.Bagherzadeh-RahmaniB.MarzettiE.JungF.et al (2024)