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Research utilizing the Broad Institute's Connectivity Map indicates it influences the expression of over 4,000 genes (~31% of the human genome), shifting gene signatures from a pathological state back to a healthier, regenerative baseline

This changes the charge and structure of the peptide at that position, potentially disrupting biological activity

[19]Liu, Zhenguo

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FIGURE 6 4 Discussion In this study, we reveal the beneficial effects of FOXO4-DRI on aortic vessels under various aging models

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