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Its impossible to know for sure what makes one patient lose more than another but certainly diet, exercise and avoiding high carb and highly refined sugars helps

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Advances in Gerontology, 01 Jan 2008, Volume 21 (Issue 3), Pages 372-381

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Heightened serotonin levels can also promote the release of dopamine and norepinephrine, resulting in changes to memory, GI problems, mood, and blood coagulation (436)

Pulsatile GH patterns are important for optimal receptor sensitivity and metabolic effects - continuous GH exposure can lead to receptor downregulation and may have different metabolic consequences than pulsatile patterns