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Bowers and colleagues demonstrated in normal men that a GH-releasing peptide given with GHRH produced GH responses substantially greater than the sum of either agent alone, and inferred from that supra-additivity that the two act through independent mechanisms

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It was originally developed for anxiety and cognitive enhancement, but its immune-modulating properties make it relevant to autoimmune conditions with neuropsychiatric components

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Consistent with these findings, our present and previous studies confirmed that endothelium-dependent vasodilation is significantly impaired in IGF- 1R KD mice [22, 44]