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Patients with diabetes or prediabetes should monitor blood glucose closely Theoretical cancer concern: improved IGF-1 has been associated with certain cancer risks in epidemiological studies

Cannav SP, Riso G, Casciaro M, Di Salvo E, Gangemi S

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Research from McMaster University shows that muscle protein synthesis rates can increase 5080% during IGF-1R activation, but if leucine availability falls below 2.53 grams per meal, the mTOR activation signal cannot translate into actual tissue accretion