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PIONEER 2 The efficacy and safety of oral semaglutide 14 mg was compared with the sodium glucose cotransporter protein 2 inhibitor empagliflozin 25 mg in 822 patients with type 2 diabetes who were uncontrolled on metformin in the 52-week, multinational, randomized, open-label PIONEER 2 trial [46]

Research shows that both are effective and well-tolerated options

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But methylene blue became an unpopular antimalarial because the patient's urine and faeces turned blue