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That said, high doses of folic acid can mask the symptoms of a Vitamin B12 deficiency

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Common Side Effects Nausea (most common) Diarrhea Reduced appetite Vomiting Constipation Stomach pain and indigestion To minimize these, doctors usually start patients on the lowest dose and increase it gradually every four weeks

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Those patients that have complications that have been shown to be ameliorated by GLP-1-based drugs, and I would say secondary prevention of cardio, of heart attacks for semaglutide