If the 95% confidence interval were to cross the non-inferiority threshold, i.e., showing the results to be inconclusive, the intramuscular treatment would remain the treatment of choice
IM B12 injection is especially appropriate when oral supplementation has been inadequate, when absorption is compromised, or when neurological symptoms are present (Stabler, New England Journal of Medicine , 2013)
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Some protocols involve longer continuous use for 6-12 months with ongoing monitoring
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