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In real-world practice, those discontinuation rates may be even higher. Andrade said the medication could be helpful for people with severe obesity, who may still have trouble losing weight on the existing GLP-1 medications, although shed like to see more data on the side effects

The retired tennis legend features in a commercial for telehealth company Ro, where she is shown using an injectable pen and navigating the companys app

GLP-1 medications are prescription drugs that require evaluation by qualified healthcare professionals

However, without the ongoing prebiotic input, bacterial populations will gradually shift back toward their pre-supplement state, and any appetite-modulating effects will fade accordingly

Compounding date

Participants taking the highest 12 mg dose of retatrutide lost an average of 28.3% of their body weight (31.9 kg) over 80 weeks, while those on the lowest 4 mg dose lost an average of 19.0% of their body weight (21.4 kg)