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"I noticed reduced cravings and an ability to pause and truly listen to my body's hunger cues, something I hadn't experienced in years

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Yang Y, Wang X, Huycke T, Moore DR, Lightfoot SA, Huycke MM

For prediabetes specifically: reversal, not just delay The SCALE Prediabetes trial demonstrated that 66.2% of participants on liraglutide (the predecessor GLP-1 agonist) reverted to normoglycaemia versus 36% on placebo at 160 weeks

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Indeed, generating a fusion or conjugation between a peptide and a carrier molecule such as an antibody Fc fragment 23,24 or a full antibody 25,26 is a well described half-life extension strategy to address their rapid clearance from circulation and improve their therapeutic potential