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Finan B, Yang B, Ottaway N et al (2015) A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

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[22] Diphenhydramine acts as a reversible, competitive antagonist-and more precisely, an inverse agonist-at the histamine H receptor, thereby stabilizing the inactive receptor conformation and preventing histamine-mediated vasodilation, increased capillary permeability, and sensory nerve activation

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