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Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system

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Together, these findings indicate that GATA2 is a key transcriptional regulator of Bdnf in lung epithelial cells, and that its downregulation during ALI contributes to the reduced BDNF expression observed in injured lungs

Investigator-assessed improvement Finding: The blinded investigator assessed the active treatment group as showing Scale 1 improvement (2650% improvement) at the final visit, while the placebo group showed Scale 0 improvement (025%)