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Alterations resulting from METex14 mutations are marked by the partial removal of the parallel membrane configuration or hindered attachment to the E3 ubiquitin-protein ligase CBL, which impedes MET protein ubiquitination and self-degradation, thereby extending the activation of subsequent signals [23, 24]

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The yeast Candida albicans can synthesise carnitine, and while it is not clear whether this is possible in bacteria, they can acquire it from the environment or from metabolic precursors, as it is used in protection against environmental stresses in some species

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