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But this timeline is not carved in stone

doi: 10.1038/ki.1993.372 82 YuenKCJBillerBMKRadovickSCarmichaelJDJasimSPantaloneKMet al

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Further confirmation of fumarate as an oncometabolite was verified by experimental data showing that tumor cells lost their ability to invade and migrate when the function of fumarate hydratase was restored by an external expression vector 131