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Tau accumulation and its association with neurodegeneration and cognitive impairments demonstrated in the current study were reported in several previous animal 60,68,72 and in clinical studies, where total tau (t-tau) and p-tau have been recognized as essential biomarkers for AD and have undergone successful validation through controlled, large-scale, multicenter studies 80

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Proc Natl Acad Sci USA 89 : 1019310197