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Osmolality Tonicity Assessment Nasal sprays should be formulated as isotonic solutions (270330 mOsm/kg) to minimize irritation and damage to the nasal mucociliary clearance apparatus

Janaszak-Jasiecka A, Siekierzycka A, Ploska A, Dobrucki IT, Kalinowski L (2021) Endothelial dysfunction driven by hypoxia-the influence of oxygen deficiency on no bioavailability

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JASN 33, 225237