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For example, in either LPS or chronic social defeat stress (CSDS) models of depression, sulforaphane prevented stress-induced increases in pro-inflammatory cytokine production and restored anti-inflammatory cytokine production (Tang et al., 2022)

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Regular exercise, reducing alcohol consumption, and avoiding exposure to toxins can also help support glutathione production in the body

As we age, our natural levels of glutathione decline, leading to visible signs of aging like wrinkles, loss of elasticity, and hyperpigmentation

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In this case, a vicious cycle can happen where increased insulin levels drive an increase in glucose SGLT2 overexpression increasing glycemic levels which in turn will increment the insulin secretion (Figure 4C)