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Acknowledgments Authors want to thank Germaine Pugh and Cassia McClain for their invaluable help in preparing the manuscript

HCG displays notably greater cAMP/PKA-mediated steroidogenic and pro-apoptotic potential compared to LH, and Leydig cell in vitro exposure to hCG results in qualitatively similar but quantitatively distinct cAMP/PKA and pERK1/2 activation patterns

However, patients should be aware of potential side effects and know when to seek medical attention

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