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Within hours at temperatures above 77F (25C), the compound begins to lose potency

Additionally, it protects the energy producing enzyme Glyceraldehyde 3-phosphate dehydrogenase from attack by nitric oxide.

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Anal Biochem 1990;184:1939

Ozempic and two similar medicines with a different active ingredient, Mounjaro and Zepbound, carry warnings about this potential side effect in their prescribing information

However, most insurance plans will only cover tirzepatide medications prescribed for their FDA-approved indication