According to still another embodiment of the present invention, the peptide Ac-Nle-cyc/o(- Asp-His-D-Phe-Arg-Trp-Lys)-OH is used for the manufacture of a medicament for treatment by multiple agent therapy with a PDE-5 inhibitor for sexual dysfunction, wherein the amount of each of the peptide Ac-Nle-cyc/o(-Asp-His-D-Phe-Arg-Trp-Lys)-OH and the PDE-5 inhibitor is not sufficient, if administered as monotherapy, to independently initiate the desired pharmacological response in the patient
The mechanism is thought to involve direct melanocyte stimulation via MC1R, promoting melanocyte proliferation and migration into depigmented areas while UV-B provides the complementary stimulus for melanocyte activation
Ethics declarations Competing interests SJW is the founder of Ridgeline Therapeutics, HN is a paid employee of Ridgeline Therapeutics and, since manuscript submission, ADW has also become a paid employee of Ridgeline Therapeutics
Rosenfield M, Li RT, Kirsch NT
Another study with 35 healthy volunteers who took 50-150 mg/day quercetin for 2 weeks showed similar results [1]
For a broader overview of what to expect while starting treatment, our post on common GLP-1 side effects is a helpful companion read
