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The bioavailability of L-carnitine from dietary sources ranges from 54% to 87%, whereas supplemental L-carnitine exhibits a much lower bioavailability, typically between 14% and 18% ( Existing polyphenol interventions show that daily intake (over 4 to 8 weeks) of berry-, grape-, or apple-derived products can modestly lower fasting TMAO ( in vitro experiments showed that punicalagin, an ellagitannin, can nearly abolish TMA formation ( in vivo investigation targeting TMAO production