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For cash-paying patients, Zepbound single-dose vials through LillyDirect cost $349 monthly for the starter dose and $499 for higher doses

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Novo Nordisk leads the market with its semaglutide brands, with Rybelsus alone accounting for nearly two-thirds of the market since its 2022 launch, according to the firm

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Not appropriate: patients on nitrate therapy (full stop), uncontrolled hypertension, significant cardiovascular disease, pregnancy, or straightforward single-mechanism dysfunction that responds well to one agent