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Berberine activates an enzyme called AMP-activated protein kinase (AMPK)often referred to as the bodys metabolic switch. This enzyme helps regulate energy balance by prompting your body to burn stored fat when energy is low, improving insulin sensitivity and supporting a healthier metabolism

doi: 10.1371/journal.pone.0240448 69 KwonH

Moreover, it has been suggested that starvation reduces liver glycogen storage and hence reduces UGT conjugative ability leading to a greater fraction of the dose being oxidised to NAPQI [77]

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Nat Cell Biol 3: 874882 Shi ZZ, OseiFrimpong J, Kala G, Kala SV, Barrios RJ, Habib GM, Lukin DJ, Danney CM, Matzuk MM, Lieberman MW (2000) Glutathione synthesis is essential for mouse development but not for cell growth in culture

[DOI] [PMC free article] [PubMed] [Google Scholar] 163.Loh J.S., Mak W.Q., Tan L.K.S., Ng C.X., Chan H.H., Yeow S.H., Foo J.B., Ong Y.S., How C.W., Khaw K.Y