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DOSING USED IN PHASE 3 STUDIES In the most recent studies from the TRIUMPH programme (Phase 3) , retatrutide was administered as follows: Route: Subcutaneous Frequency: Once weekly Study duration: Approximately 68 weeks Phase 3 Schedule Recommended Dosage (Clinical Research Escalation Model) Retatrutide is administered once weekly using a gradual dose escalation to improve tolerability

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Early data further suggest Retatrutide might offer neuroprotective benefits, possibly due to improved metabolic health and reduced systemic inflammation, pointing to a broader therapeutic potential in preserving cognitive function and preventing dementia

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doi: 10.1111/j.1600-0587.2013.00436.x 20

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