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Abbreviations 6-OHDA: 6-Hydroxydopamine ADP: Adenosine diphosphate AKT: Serine/threonine-protein kinase/protein kinase B ALA: Alpha-lipoic acid ALC: Acetyl-L-carnitine AMPK: AMP-activated protein kinase AP-1: Activator protein 1 ARE: Antioxidant response element Arg-1: Arginase-1 ASK1: Apoptosis signal-regulating kinase 1 ATP: Adenosine triphosphate Axl: Tyrosine-protein kinase receptor Bax: Bcl-2-like protein 4 Bcl-2: B-cell lymphoma 2 Bcl-3: B-cell lymphoma 3 BDNF: Brain-derived neurotrophic factor CDDO: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid CHO: Carbohydrate chrDNA: Chromosomal DNA CKD: Chronic kidney disease CNS: Central nervous system CoA: Coenzyme A COPD: Chronic obstructive pulmonary disease CoQ10: Coenzyme Q10 COX-2: Cyclooxygenase-2 CREB: CAMP response element-binding protein CVDs: Cardiovascular diseases CYP1A2: Cytochrome P450 1A2 DHALA: Dihydrolipoic acid DM: Diabetes mellitus DMG: Dimethylglycine DNA: Deoxyribonucleic acid DOX: Doxorubicin DRP1: Dynamin-related protein 1 EC: Epicatechin chloride ECC: Epigallocatechin chloride ECG: Epicatechin gallate ECM: Extracellular matrix EGb761: Ginkgo biloba Extract commercial product EGCG: Epigallocatechin gallate eGFR: Estimated glomerular filtration rate EMT: Epithelial-mesenchymal transition eNOS: Endothelial nitric oxide synthase ERK: Extracellular signal-regulated kinase ETC: Electron transport chain FAD: Flavin adenine dinucleotide FIS1: Mitochondrial fission 1 protein FMN: Flavin mononucleotide FOXOs: Forkhead-box transcription factors FSF: Flammer syndrome phenotype FXR: Farnesoid X receptor GABA: Gamma-aminobutyric acid GAS6: Growth arrest-specific protein 6 GBE: Ginkgo biloba Extract GLUT-4: Glucose transporter type 4 GSK-3: Glycogen synthase kinase-3 beta GST: Glutathione S-transferase HbA1c: Glycosylated hemoglobin HDFs: Human dermal fibroblasts Hhcy: Hyperhomocysteinemia HIF: Hypoxia-inducible factor HO: Hydroxyl radicals HO-1: Heme oxygenase 1 HOO: Hydroperoxyl radicals IBS: Irritable bowel syndrome IKK: Kappa kinase IL: Interleukin iNOS: Inducible nitric oxide synthase JAK: Janus kinase JNK: C-Jun amino-terminal kinases Keap1: Kelch-like ECH-associated protein 1 LC: L-Carnitine LDL: Low-density lipoprotein LPS: Lipopolysaccharide MAPK: Mitogen-activated protein kinase MEF2P: Mitochondrial elongation factor miRNA: Small non-coding RNA MMP: Mitochondrial membrane potential MMP-1: Matrix metalloproteinase-1 MMP-9: Matrix metalloproteinase-9 mRNA: Messenger RNA mtDNA: Mitochondrial DNA mTOR: Mammalian target of rapamycin NAD + : Nicotinamide adenine dinucleotide NADP + : Nicotinamide adenine dinucleotide phosphate NADPH: Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor kappa B NO: Nitric oxide Notch1: Neurogenic locus notch homolog protein 1 NQO1: NAD(P)H quinone oxidoreductase 1 NR1C: Nuclear receptor 1C NRF-1: Nuclear respiratory factor 1 Nrf2: Nuclear factor-erythroid 2-related factor 2 OA: Oleanolic acid OADs: Oleanolic acid derivatives OPA1: Mitochondrial dynamin like GTPase OSA: Obstructive sleep apnea p38: Mitogen-activated protein kinase family p53: Protein encoded by TP53 gene PARP1: Poly ADP-ribose polymerase 1 PCr: Phosphocreatine PGC1: Peroxisome proliferator-activated receptor coactivator 1-alpha PGE2: Prostaglandin E2 PI3K: Phosphoinositide 3-kinase PINK1: PTEN-induced kinase 1 PKB: Protein kinase B PLP: Pyridoxal 5-phosphate PolyQ: Polyglutamine PPD: Protopanaxadiol PPPM/3PM: Predictive preventive personalized medicine PPT: Protopanaxatriol PQQ: Pyrroloquinoline quinone PTEN: Phosphatase and tensin homolog RAS: Rat sarcoma virus oncogene family RNA: Ribonucleic acid RNS: Reactive nitrogen species ROS: Reactive oxygen species S6K: Ribosomal protein S6 kinase SAPK: Stress-activated protein kinases SGPL1: Sphingosine-1-phosphate lyase 1 SHMT2: Serine hydroxymethyltransferase 2 SIR2: Silent information regulator 2 SIRTs: Sirtuins (NAD + -dependent deacetylases) STAT3: Signal transducer and activator of transcription 3 STK11: Serine/threonine kinase 11 TBK1: TANK-binding kinase 1 TCA: Tricarboxylic acid cycle TFAM: Mitochondrial transcription factor A TGF-: Transforming growth factor-beta TLR: Toll-like receptor TMG: Trimethylglycine TNF-: Tumor necrosis factor alpha tRNA: Transfer RNA UCPs: Uncoupling proteins UVB: Ultraviolet B light VDR: Vitamin D receptor VEGF: Vascular endothelial growth factor VEGFR2: Vascular endothelial growth factor receptor 2 Wnt: Wingless-related integration site References Golubnitschaja O

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Empagliflozin and metformin work in different ways, which is why the combination may be used when a clinician wants both mechanisms in one tablet