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Still, how soon you notice any benefit depends on why you are using it, your dose, and your overall health

a high BMI is a marker of obesity

It probably had to do with the weight status, Thyfault says

Furthermore, antagonizing the GIPR reduced tirzepatide-stimulated insulin secretion in each islet set, demonstrating that activity at the GIPR is necessary for tirzepatide to stimulate insulin secretion in isolated human islets

Mounjaro 10 mg, 15 mg, or 5 mg led to a weight loss ranging from 7.7 kg (17 lb) to 11.4 kg (25 lb), compared to semaglutide (5.9 kg, 13 lb)

This titration period is necessary to acclimate the body to semaglutide without overwhelming side effects