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From a three-dimensional structural perspective, SIRT1 is composed of a highly conserved Rossmann-fold catalytic core domain and an additional structural domain comprising both a zinc-binding module and a helical module (Haigis and Sinclair 2010)

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Studies in the Journal of Clinical Investigation demonstrate CJC-1295 with DAC increases IGF-1 levels by 200-300% for up to one week after a single injection

The key difference is duration and strength