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For example, a patient with type 2 diabetes on GLP-1 scheduled for hip replacement may continue the agent until 1 to 2 weeks pre-op if weight loss is modest, but stop earlier if gastroparesis or severe nausea is present

The manufacturers in animal studies have said that there could be adverse outcomes

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And there are really three different paths by which people obtain these peptides

Islets were obtained from normoglycemic donors, according to the local ethics rules (including next-of-kin consent) and isolation techniques, and cultured in RPMI supplemented with 5.5 mM d-glucose, 10% FCS, 100 U penicillin, 100 g streptomycin, and 0.25 g l 1 fungizone (37 C, 5% CO 2 ) 28

Endocrinology, 149, 47684777