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Concomitantly with the development of resistance the up-regulation of a hydrogen-peroxide inducible GST was observed that might contribute to the elimination of cytotoxic reactive metabolites containing an electrophilic moiety (Shibu et al., 2012)

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Importantly, GLP-1 RAs cause weight loss, reduce hypoglycaemia (compared with sulfonylureas and insulin), and are one of the most effective glucose-lowering medications, which are effects that we have not incorporated [7]

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, with the molecular formula CHNOS and molecular weight of 307.32 g/mol, is a tripeptide consisting of three amino acids: glutamate (glutamic acid), cysteine, and glycine

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