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There have been rare reports of more severe reactions to prolotherapy, such as ligament rupture or spinal headaches, when injections were done in delicate areas or not using image guidance

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Here's what the safety risks are potentially with it, and here's what we could do that's probably going to do the same thing, if not better, but in a safer way, with more predictable outcomes. To help other health care providers navigate these conversations, he wrote a review of unapproved peptides for musculoskeletal performance and athletic performance, which was published online earlier this month in the journal Sports Medicine