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The glucagon receptor arm the feature that distinguishes retatrutide from earlier-generation incretin compounds drives hepatic glucose metabolism, lipid oxidation, and energy expenditure effects, all absent from GLP-1 mono-agonists and dual GLP-1/GIP agonists
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The choice between them for glycemic control alone would likely favor tirzepatide simply because it is available and proven, while retatrutide remains investigational
This can stimulate fat burning and discourage fat storage, which may aid in weight loss