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In contrast, Trolox, a non-thiol drug, was unable to revert FA cytotoxicity (Supplementary Fig

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Melatonin has also been shown to alleviate the symptoms of both macrovascular and microvascular diseases

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Unlike many other compounds, it is remarkably stable, which has made it a primary focus for scientists looking to accelerate the healing of tendons, muscles, and ligaments

For instance, mutations or overexpression of genes involved in the DNA repair machinery, such as BRCA2, can promote resistance by enhancing the repair of mitoxantrone-induced DNA damage (62)