BMC Cancer 23 , 594 (2023)
It is available through standard pharmacy channels with a prescription
In initial preclinical studies, orforglipron has been shown to stimulate insulin secretion and reduce food consumption in non-human primates, and it is fully efficacious at lowering hyperglycemia in mice expressing the human GLP-1R but inactive in GLP-1R knockout animals
95% CI, 0.74-1.39) were also assessed
This weekly dosing schedule is consistent with other agents in the incretin-based injectable class, such as semaglutide (Ozempic/Wegovy) and tirzepatide (Mounjaro), and is designed to maintain stable plasma drug concentrations throughout the week whilst minimising the burden of frequent injections
Gastrointestinal Distress: Nausea, vomiting, and diarrhea are common during dose escalation