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N Engl J Med (2004) 351(16):161926.10.1056/NEJMoa040576 281 RowlandsMAGunnellDHarrisRVattenLJHollyJMPMartinRM

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V plasma,br is the physiological plasma volume (mL/g of brain tissue) within the brain, which is about 1.26% of the brain weight of neonatal mice ( V app is the apparent volume of distribution of 7,8-DHF in plasma within the brain and it depends on the protein binding of the drug in plasma

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Low expression of EPAC mRNA and its effector RAP1-GTP protein in primary melanoma correlate with better recurrence-free survival