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If you have active cancer or a history of cancer, this is a legitimate reason to avoid it since promoting blood vessel growth could theoretically feed tumors

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One study on women looking at colon cancer risk found that women with a high polygenic risk score for colon cancer had a significant reduction in risk of CRC with menopausal HRT.[ref] Another study showed that several genetic variants statistically impacted the risk of breast cancer with HRT, but it concluded that more studies are needed

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