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And the expression of downstream gene significantly reduced after treated inhibitors of PI3K, Akt, and mTOR

To identify the full extent of the differential signaling responses to ligand stimulation between WT-IR and L973F-IR, we also compared the fold changes of each phosphosite between basal and stimulated conditions in these 2 cell types for both up- and downregulated phosphorylation in a volcano plot (Figure 3C)

Neuro Endocrinol Lett 41(1):19 Al-Jowari SA-K (2024) Physiological impacts of cauliflower in hyperthyroid rabbits

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Most people find that symptoms become manageable or disappear entirely by week four, though a small percentage continue experiencing mild side effects for longer