The bottom line: With appropriate monitoring (especially in patients with active suicidal ideation or severe eating disorders), GLP-1s appear safe from a psychiatric standpoint
Ensure adequate fluid intake and contact your GP if symptoms are severe or prolonged Changes in mood or mental health : Whilst sertraline treats depression and anxiety, any worsening of mental health symptoms, emergence of suicidal thoughts, or unusual behavioural changes should be reported immediately Appetite changes : Significant loss of appetite or difficulty eating adequate nutrition requires medical review Signs of pancreatitis : Severe abdominal pain radiating to the back, nausea, and vomiting warrant urgent medical assessment, as GLP-1 agonists carry a small risk of pancreatitis [1] [5] Gallbladder problems : Wegovy and rapid weight loss can increase the risk of gallstones and gallbladder inflammation
Changes in synaptic plasticity and glutamate receptors in type 2 diabetic KK-Ay mice
Drinking water before meals may enhance satiety
FASEB J 23:5867 Wang Z, Thurmond DC (2009) Mechanisms of biphasic insulin-granule exocytosisroles of the cytoskeleton, small GTPases and SNARE proteins
When skin is exposed to ultraviolet radiation from the sun or tanning beds, it triggers melanin production as a protective response to DNA damage
