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Stepping back, its clear that BED is a serious disease and clinicians who treat it have limited tools

GIP is the main incretin hormone in healthy people, causative of most the incretin effects but the insulin response after GIP secretion in T2DM is reduced [12]

As with any weight loss medication, it should be used in combination with a healthy diet and exercise program for the best results

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The modifications made to human GLP-1 include: Amino acid substitutions that resist DPP-4 enzyme degradation Attachment of fatty acid chains (acylation) as seen in semaglutide and liraglutide Fusion with immunoglobulin fragments (as in dulaglutide) to increase molecular size These changes are designed using rational drug design principles and implemented through biotechnology