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Other common symptoms of a cleft lip and palate include: Difficulty breathing through the nose Speech issues Dental problems Ear infections (more common in cleft palate) Hearing loss Nasal and sinus issues Speech and language delays Psychological and emotional challenges There are also many other congenital syndromes which cleft lip and palate form a part of which can give rise to other related symptoms, including heart defects, stunted growth, and intellectual disabilities

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CCH increased tau hyperphosphorylation and reduced autophagy in these mice, leading to increased aggregation of NFTs and worsened neurodegeneration 140

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