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J Biol Chem (2005) 280:111406.10.1074/jbc.M412242200 84 SeckTBaronRHorneWC

C18:2-9t,12c

Scientists found that a hormone in the Gila monsters venom called exendin-4 could be used to treat type 2 diabetes

DiStefano JK

Methods In this phase 3a, double-blind, randomized, placebo-controlled trial conducted in 12 countries, we assigned adults with a body-mass index of 27 or more, a glycated hemoglobin level of 7 to 10%, and type 2 diabetes in a 3:1 ratio to receive once-weekly cagrilintide-semaglutide (2.4 mg each) or placebo, along with lifestyle intervention, for 68 weeks

It carries four substitutions, notably D-Ala at position 2, studied in vitro for increased resistance to dipeptidyl-peptidase-IV (DPP-IV) cleavage