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Previous research found that the salivary cortisol levels detected in a maximal progressive test using a cycle ergometer were significantly higher under the hot conditions (40 C) than under normal conditions (22 C) in nine young healthy men 23

The difference is more structural than functional

These conditions may amplify GLP-1 side effects, particularly during menstruation

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First Week Side Effects Beyond Nausea Beyond nausea, patients commonly experience fatigue, mild dizziness, or changes in taste during the first seven days after starting semaglutide