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Inhibition of MetAP2 reduced fibroblast proliferation and collagen deposition in BLM-treated mice, indicating its potential as a pro-fibrotic mediator [127, 128]

These different complementary interventions were reported to be successful, with the dysmetabolic impairment found to be significantly reduced (6, 7, 9, 10, 19, 27)

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Equally important is a patients readiness for a long-term, medically guided approach